diff --git a/Changelog.md b/Changelog.md
index 27d449b4f..7d7cdcb2b 100644
--- a/Changelog.md
+++ b/Changelog.md
@@ -9,6 +9,7 @@
 - PAC 自动代理脚本内容无法动态调整
 - 兼容从旧版服务模式升级
 - Monaco 编辑器的行数上限
+- 已删除节点在手动分组中导致配置无法加载
 
 <details>
 <summary><strong> ✨ 新增功能 </strong></summary>
diff --git a/src-tauri/src/enhance/mod.rs b/src-tauri/src/enhance/mod.rs
index df63f3220..24f0764a1 100644
--- a/src-tauri/src/enhance/mod.rs
+++ b/src-tauri/src/enhance/mod.rs
@@ -17,7 +17,7 @@ use crate::constants;
 use crate::utils::dirs;
 use crate::{config::Config, utils::tmpl};
 use clash_verge_logging::{Type, logging};
-use serde_yaml_ng::Mapping;
+use serde_yaml_ng::{Mapping, Value};
 use smartstring::alias::String;
 use std::collections::{HashMap, HashSet};
 use tokio::fs;
@@ -501,6 +501,88 @@ fn apply_builtin_scripts(
     config
 }
 
+fn cleanup_proxy_groups(mut config: Mapping) -> Mapping {
+    const BUILTIN_POLICIES: &[&str] = &["DIRECT", "REJECT", "REJECT-DROP", "PASS"];
+
+    let proxy_names = config
+        .get("proxies")
+        .and_then(|v| v.as_sequence())
+        .map(|seq| {
+            seq.iter()
+                .filter_map(|item| match item {
+                    Value::Mapping(map) => map
+                        .get("name")
+                        .and_then(Value::as_str)
+                        .map(|name| name.to_owned().into()),
+                    Value::String(name) => Some(name.to_owned().into()),
+                    _ => None,
+                })
+                .collect::<HashSet<String>>()
+        })
+        .unwrap_or_default();
+
+    let group_names = config
+        .get("proxy-groups")
+        .and_then(|v| v.as_sequence())
+        .map(|seq| {
+            seq.iter()
+                .filter_map(|item| {
+                    item.as_mapping()
+                        .and_then(|map| map.get("name"))
+                        .and_then(Value::as_str)
+                        .map(std::convert::Into::into)
+                })
+                .collect::<HashSet<String>>()
+        })
+        .unwrap_or_default();
+
+    let provider_names = config
+        .get("proxy-providers")
+        .and_then(Value::as_mapping)
+        .map(|map| {
+            map.keys()
+                .filter_map(Value::as_str)
+                .map(std::convert::Into::into)
+                .collect::<HashSet<String>>()
+        })
+        .unwrap_or_default();
+
+    let mut allowed_names = proxy_names;
+    allowed_names.extend(group_names);
+    allowed_names.extend(provider_names.iter().cloned());
+    allowed_names.extend(BUILTIN_POLICIES.iter().map(|p| (*p).into()));
+
+    if let Some(Value::Sequence(groups)) = config.get_mut("proxy-groups") {
+        for group in groups {
+            if let Some(group_map) = group.as_mapping_mut() {
+                let mut has_valid_provider = false;
+
+                if let Some(Value::Sequence(uses)) = group_map.get_mut("use") {
+                    uses.retain(|provider| match provider {
+                        Value::String(name) => {
+                            let exists = provider_names.contains(name.as_str());
+                            has_valid_provider = has_valid_provider || exists;
+                            exists
+                        }
+                        _ => false,
+                    });
+                }
+
+                if let Some(Value::Sequence(proxies)) = group_map.get_mut("proxies") {
+                    proxies.retain(|proxy| match proxy {
+                        Value::String(name) => {
+                            allowed_names.contains(name.as_str()) || has_valid_provider
+                        }
+                        _ => true,
+                    });
+                }
+            }
+        }
+    }
+
+    config
+}
+
 async fn apply_dns_settings(mut config: Mapping, enable_dns_settings: bool) -> Mapping {
     if enable_dns_settings && let Ok(app_dir) = dirs::app_home_dir() {
         let dns_path = app_dir.join(constants::files::DNS_CONFIG);
@@ -595,6 +677,8 @@ pub async fn enhance() -> (Mapping, Vec<String>, HashMap<String, ResultLog>) {
     // builtin scripts
     let mut config = apply_builtin_scripts(config, clash_core, enable_builtin);
 
+    config = cleanup_proxy_groups(config);
+
     config = use_tun(config, enable_tun);
     config = use_sort(config);
 
@@ -607,3 +691,175 @@ pub async fn enhance() -> (Mapping, Vec<String>, HashMap<String, ResultLog>) {
 
     (config, exists_keys, result_map)
 }
+
+#[cfg(test)]
+mod tests {
+    use super::cleanup_proxy_groups;
+
+    #[test]
+    fn remove_missing_proxies_from_groups() {
+        let config_str = r#"
+proxies:
+  - name: "alive-node"
+    type: ss
+proxy-groups:
+  - name: "manual"
+    type: select
+    proxies:
+      - "alive-node"
+      - "missing-node"
+      - "DIRECT"
+  - name: "nested"
+    type: select
+    proxies:
+      - "manual"
+      - "ghost"
+"#;
+
+        let mut config: serde_yaml_ng::Mapping =
+            serde_yaml_ng::from_str(config_str).expect("Failed to parse test yaml");
+        config = cleanup_proxy_groups(config);
+
+        let groups = config
+            .get("proxy-groups")
+            .and_then(|v| v.as_sequence())
+            .cloned()
+            .expect("proxy-groups should be a sequence");
+
+        let manual_group = groups
+            .iter()
+            .find(|group| {
+                group.get("name").and_then(serde_yaml_ng::Value::as_str) == Some("manual")
+            })
+            .and_then(|group| group.as_mapping())
+            .expect("manual group should exist");
+
+        let manual_proxies = manual_group
+            .get("proxies")
+            .and_then(|v| v.as_sequence())
+            .expect("manual proxies should be a sequence");
+
+        assert_eq!(manual_proxies.len(), 2);
+        assert!(
+            manual_proxies
+                .iter()
+                .any(|p| p.as_str() == Some("alive-node"))
+        );
+        assert!(manual_proxies.iter().any(|p| p.as_str() == Some("DIRECT")));
+
+        let nested_group = groups
+            .iter()
+            .find(|group| {
+                group.get("name").and_then(serde_yaml_ng::Value::as_str) == Some("nested")
+            })
+            .and_then(|group| group.as_mapping())
+            .expect("nested group should exist");
+
+        let nested_proxies = nested_group
+            .get("proxies")
+            .and_then(|v| v.as_sequence())
+            .expect("nested proxies should be a sequence");
+
+        assert_eq!(nested_proxies.len(), 1);
+        assert_eq!(nested_proxies[0].as_str(), Some("manual"));
+    }
+
+    #[test]
+    fn keep_provider_backed_groups_intact() {
+        let config_str = r#"
+proxy-providers:
+  providerA:
+    type: http
+    url: https://example.com
+    path: ./providerA.yaml
+proxies: []
+proxy-groups:
+  - name: "manual"
+    type: select
+    use:
+      - "providerA"
+      - "ghostProvider"
+    proxies:
+      - "dynamic-node"
+      - "DIRECT"
+"#;
+
+        let mut config: serde_yaml_ng::Mapping =
+            serde_yaml_ng::from_str(config_str).expect("Failed to parse test yaml");
+        config = cleanup_proxy_groups(config);
+
+        let groups = config
+            .get("proxy-groups")
+            .and_then(|v| v.as_sequence())
+            .cloned()
+            .expect("proxy-groups should be a sequence");
+
+        let manual_group = groups
+            .iter()
+            .find(|group| {
+                group.get("name").and_then(serde_yaml_ng::Value::as_str) == Some("manual")
+            })
+            .and_then(|group| group.as_mapping())
+            .expect("manual group should exist");
+
+        let uses = manual_group
+            .get("use")
+            .and_then(|v| v.as_sequence())
+            .expect("use should be a sequence");
+        assert_eq!(uses.len(), 1);
+        assert_eq!(uses[0].as_str(), Some("providerA"));
+
+        let proxies = manual_group
+            .get("proxies")
+            .and_then(|v| v.as_sequence())
+            .expect("proxies should be a sequence");
+        assert_eq!(proxies.len(), 2);
+        assert!(proxies.iter().any(|p| p.as_str() == Some("dynamic-node")));
+        assert!(proxies.iter().any(|p| p.as_str() == Some("DIRECT")));
+    }
+
+    #[test]
+    fn prune_invalid_provider_and_proxies_without_provider() {
+        let config_str = r#"
+proxy-groups:
+  - name: "manual"
+    type: select
+    use:
+      - "ghost-provider"
+    proxies:
+      - "ghost-node"
+      - "DIRECT"
+"#;
+
+        let mut config: serde_yaml_ng::Mapping =
+            serde_yaml_ng::from_str(config_str).expect("Failed to parse test yaml");
+        config = cleanup_proxy_groups(config);
+
+        let groups = config
+            .get("proxy-groups")
+            .and_then(|v| v.as_sequence())
+            .cloned()
+            .expect("proxy-groups should be a sequence");
+
+        let manual_group = groups
+            .iter()
+            .find(|group| {
+                group.get("name").and_then(serde_yaml_ng::Value::as_str) == Some("manual")
+            })
+            .and_then(|group| group.as_mapping())
+            .expect("manual group should exist");
+
+        let uses = manual_group
+            .get("use")
+            .and_then(|v| v.as_sequence())
+            .expect("use should be a sequence");
+        assert_eq!(uses.len(), 0);
+
+        let proxies = manual_group
+            .get("proxies")
+            .and_then(|v| v.as_sequence())
+            .expect("proxies should be a sequence");
+        assert_eq!(proxies.len(), 1);
+        assert_eq!(proxies[0].as_str(), Some("DIRECT"));
+    }
+}